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There are many different factors that can play a role in the development of a sore throat. Sinus drainage called post nasal drip can contribute to throat issues. Common viruses, such as the viruses associated with mononucleosis (mono) and the flu can bring blisters and soreness in the mouth and throat. Bacterial infections, such as strep throat, cause soreness.

Throat dryness and soreness can develop when you breathe through your mouth or smoke tobacco. Some medical treatments, such as chemotherapy and taking certain antibiotics, can create a throat to become sore. A sore throat that lasts for more than two weeks can be a sign of a serious illness, including throat cancer and AIDS.
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